INFLUENZA VIRUS VACCINES AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide influenza hemagglutinin stem domain polypeptides useful for presenting one or more relatively conserved antigenic regions to the host immune system in order to elicit an immune response capable of cross reacting with plural influenza strains.SOLUTION: Provided is a polypeptide comprising: a. an influenza hemagglutinin HA1 domain of which N terminal stem segment is covalently linked to a linker of 1-50 heterologous residues that is further covalently linked to the C terminal stem segment of HA1, where the HA1 domain is in tertiary or quaternary association with b. influenza hemagglutinin HA2 domain. The polypeptide may be useful for eliciting immune response to plural influenza strains.SELECTED DRAWING: Figure 3