<p>Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin alpha and rifaximin beta , and a poorly crystalline form named rifaximin y have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.</p>
申请公布号
EP1676847(B1)
申请公布日期
2009.01.28
申请号
EP20060004219
申请日期
2004.03.09
申请人
ALFA WASSERMANN S.P.A.
发明人
VISCOMI, GIUSEPPE C.;CAMPANA, MANUELA;BRAGA, DARIO;CONFORTINI, DONATELLA;CANNATA, VINCENZO;SEVERINI, DENIS;RIGHI, PAOLO;ROSINI, GOFFREDO