METHOD FOR PREPARING VORAPAXAR SULFATE, AND INTERMEDIATE AND PREPARATION METHOD THEREFOR

摘要

Disclosed are a method for preparing an anticoagulant, and an intermediate and a preparation method therefor. Provided is a method for preparing an intermediate IV of vorapaxar sulfate, which comprises the following steps: in an organic solvent, performing an oxidation reaction on compound III and an oxidant, so as to obtain the intermediate IV of vorapaxar sulfate. The preparation method of the present invention has a simple operation, mild reaction conditions, a high reaction conversion rate and a high yield; and the prepared product has a high purity, a low production cost, a simple post-treatment, and is suitable for industrial production.