BMP7 MUTANT-ALBUMIN COINTEGRATE, AND RENAL DISEASE THERAPEUTIC AGENT CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide novel renal disease therapeutic agents, particularly novel renal disease therapeutic agents in which BMP7 having a kidney repair function but required for daily administration due to the problem of low clustering in the kidney is improved.SOLUTION: The present invention provides a fusion protein consisting of a cointegrate of a sugar chain deficient BMP7 mutant and a human serum albumin (where, BMP7 mutant and human albumin are bounded directly or through a spacer consisting of amino acids of 2-20). The invention also provides a fusion protein consisting of a sugar chain deficient BMP7 mutant, human serum albumin, and kidney-targeting peptide.SELECTED DRAWING: Figure 1