| 摘要 |
The present invention relates to compounds of formula wherein A is R is lower alkyl, —(CH2)z-C3-7-cycloalkyl or —(CH2)z—C4-6-heterocycloalkyl, which are optionally substituted by one to three hydroxy, lower alkyl, lower alkoxy or halogen, or is (endo)-7-oxabicyclo[2.2.1]heptan-2-yl; X is CH or N; Y1 is CR3 or N; Y2 is CR4; or or Y1 and Y2 may form together with the carbon atoms to which they are attach Y3 is N; Y4 is N; Y5 is NR7; R1 is hydrogen or halogen; R2 is hydrogen, halogen, cycloalkyl, lower alkyl or lower alkoxy; R3 is hydrogen, halogen, CN, —C(O)NH2, —C(O)NHCH3 or —C(O)N(CH3)2; R4 is hydrogen, a 5 or 6 membered heteroaryl or heterocyclyl group, selected from the group consisting of or is phenyl, —C(O)NH2, —CH2C(O)NH2, —C(O)NHCH3, —C(O)NH-cycloalkyl, —C(O)N(CH3)2, —NHC(O)O-lower alkyl, CN, lower alkoxy, lower alkoxy substituted by halogen, halogen or S(O)2CH3; R5 is phenyl; R6 is phenyl or thiazol-2-yl; R7 is pyridin-2-yl or pyrimidin-4-yl; p is 0 or 1; m is 1, 2 or 3; z is 0 or 1; or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment or prophylaxis of Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders. |
