GLP-1 EXENDIN-4 PEPTIDE ANALOGS AND USES THEREOF

摘要

The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the 5 polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP 1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects. 6061765_1 (GHMatters) P52050.AU.3 LEOWNR