发明名称 |
ANTI-CLAUDIN 1 MONOCLONAL ANTIBODIES FOR THE PREVENTION AND TREATMENT OF HEPATOCELLULAR CARCINOMA |
摘要 |
Use of anti-Claudin 1 monoclonal antibodies and pharmaceutical compositions thereof, for the prevention and/or treatment of hepatocellular carcinoma in patients suffering from liver disease, in particular liver disease that is not associated with HCV infection or in patients who have been cured from HCV infection. Methods of preventing and/or treating hepatocellular carcinoma by administration of such a monoclonal antibody, or a pharmaceutical composition thereof, are also described. Experimental results with the hepatocarcinoma cell line HuH-7.5.1 are given. |
申请公布号 |
WO2016146809(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2016EP55942 |
申请日期 |
2016.03.18 |
申请人 |
INSTITUT HOSPITALIER UNIVERSITAIRE DE STRASBOURG;INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);UNIVERSITE DE STRASBOURG |
发明人 |
BAUMERT, Thomas;ROBINET, Eric;ZEISEL, Mirjam |
分类号 |
C07K16/28;A61K39/395;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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