POLYCATION-FUNCTIONALIZED NANOPOROUS SILICON CARRIER FOR SYSTEMIC DELIVERY OF GENE SILENCING AGENTS

摘要

Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.

主权项

1. A composition for the sustained-release delivery of an active agent to a target cell of a subject in need thereof, comprising: (a) a population of polycation-functionalized nanoporous silicon first-stage particles, and (b) a population of second-stage particles contained substantially within the interior of the population of the first-stage particles, and wherein the second-stage particles comprise at least a first active agent.