| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to method of producing cyclic esters containing unsaturated functional groups of formula I, where each x is same and is integer ranging from 0 to 12; where each Rand each Rwhen are present, independently hydrogen, hydroxy, amino, thio, halogen, substituted or unsubstituted C-Calkilom, substituted or unsubstituted C-Calkoksi, substituted or unsubstituted C-Calkiltio, substituted or unsubstituted C-Calkilaminom, or substituted or unsubstituted C-Cgidroksialkilom; provided that each Ris the same and each Ris the same; where Ris hydrogen, hydroxy, amino, thio, halogen, substituted or unsubstituted C-Calkilom, substituted or unsubstituted C-Calkoksi, substituted or unsubstituted C-Calkiltio, substituted or unsubstituted C-Calkilaminom, or substituted or unsubstituted C-Cgidroksialkilom; and whereis in some cases bond; which involves heating of liquid reaction medium containing oligomeric α-hydroxyacid of formula II or its salt, where n is integer from 2 to 30 and where x, R, R, Randis as defined above, at temperature of approximately 150 °C to approximately 300 °C to form cyclic ester, along with removal of liquid reaction medium composition containing cyclic ester.EFFECT: these compounds can be used for preparing biocompatible and biodegradable polymers, which can be used as carriers for drug delivery.16 cl, 2 ex |
