发明名称 |
Genetic Inhibition by Double-Stranded RNA |
摘要 |
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods. |
申请公布号 |
US2016208280(A1) |
申请公布日期 |
2016.07.21 |
申请号 |
US201615004136 |
申请日期 |
2016.01.22 |
申请人 |
Carnegie Institution of Washington ;University of Massachusetts |
发明人 |
Fire Andrew;Kostas Stephen;Montgomery Mary;Timmons Lisa;Xu SiQun;Tabara Hiroaki;Driver Samuel E.;Mello Craig c. |
分类号 |
C12N15/82;C12N15/113 |
主分类号 |
C12N15/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Washington DC US |