Methods for Diagnosing Onset and Monitoring Progression of Huntington's Disease

摘要

The present invention relates to methods of diagnosing onset, monitoring progression and initiating therapies for a neurological disorder, such as juvenile- or adult-onset Huntington's disease, by comparing the levels of one or more plasma and/or cerebrospinal fluid biomarkers. The invention further relates to N-methyl proline, beta-tocopherol, cortisone, pyruvate, phosphate, and trans-4-hydroxyproline as plasma and/or cerebrospinal fluid biomarkers of onset and progression of a neurological disorder, such as Huntington's disease.

主权项

1. A method of diagnosing onset or progression of Huntington's disease (HD) comprising:
obtaining a sample from a subject, measuring levels of at least one biomarker in said sample, wherein the at least one biomarker comprises one of N-methyl proline or beta-tocopherol; comparing the levels of said biomarkers to a reference value, and diagnosing said subject with an onset of HD when the levels of said biomarkers from said subject differ from those of the reference value and treating said subject with a HD therapy.