发明名称 ASSEMBLIES AND METHODS FOR REDUCING OPTICAL CROSSTALK IN PARTICLE PROCESSING SYSTEMS
摘要 The present disclosure relates to optical crosstalk reduction in particle processing (e.g., cytometry including flow cytometry using microfluidic based sorters, drop formation based sorters, and/or cell purification) systems and methods in order to improve performance. More particularly, the present disclosure relates to assemblies, systems and methods for minimizing optical crosstalk during the analyzing, sorting, and/or processing (e.g., purifying, measuring, isolating, detecting, monitoring and/or enriching) of particles (e.g., cells, microscopic particles, etc.). The exemplary systems and methods for crosstalk reduction in particle processing systems (e.g., cell purification systems) may be particularly useful in the area of cellular medicine or the like. The systems and methods may be modular and used singly or in combination to optimize cell purification based on the crosstalk environment and specific requirements of the operator and/or system.
申请公布号 US2016327469(A1) 申请公布日期 2016.11.10
申请号 US201615148474 申请日期 2016.05.06
申请人 CYTONOME/ST, LLC 发明人 Sharpe Johnathan Charles;Perrault, JR. Donald Francis;Machado Emanuel Tito Mendes;Morad Blair D.
分类号 G01N15/14 主分类号 G01N15/14
代理机构 代理人
主权项 1. A particle processing system comprising: a radiation source system configured to optically interrogate a plurality of interrogation sites; a signal detection system including a detector configured to receive an optical signal emitted from at least one of the plurality of interrogation sites; wherein the radiation source system is configured to simultaneously interrogate a first interrogation region with a first modulated signal frequency and a second interrogation region with a second modulated signal frequency, and further comprising: an electronic system configured to separate a first optical signal received from a first one of the plurality of interrogation sites from a detected interleaved optical signal that also includes a second optical crosstalk signal received from a second one of the plurality of interrogation sites, wherein the electronic system is configured to separate the first optical signal from the second optical crosstalk signal based on a recognition of the modulated signal frequencies.
地址 Boston MA US