SEGMENTED RNA GENOME VIRUSES AND THEIR MANIPULATION

摘要

The present invention provides a segmented virus which comprises a RNA genome comprising a first and a second segment which interact during virion assembly by base pairing between complementarity motifs on the first and second segments; wherein the complementarity motifs on the first and second segments are mutated such that base pairing is maintained between the first and second segment but such that the complementarity motif does not base pair with an equivalent interacting complementarity motif on a segment from a wild type virus.