DEVICES, COMPOSITIONS AND METHODS FOR BONE AND TISSUE AUGMENTATION

摘要

Various polymeric materials and delivery systems are described, along with systems and methods for using them for bone and tissue augmentation, such as for the stabilization and/or correction of spinal compression fractures.

主权项

1. A polymer composition for augmentation and support of bone tissue, comprising a side chain crystallizable polymer, wherein:
(i) the polymer composition has a solid state when within a first temperature range, the first temperature range selected to substantially correspond to temperatures generally found in anatomical bone structures of living mammals, the solid state having mechanical properties suitable for supporting and/or augmenting bone tissue; (ii) the polymer composition has a second transition temperature range, the second transition temperature range being above the first temperature range; (iii) the polymer composition has an extrudable fluid state when in a third temperature range, the third temperature range being above the second temperature range; the third temperature range selected to correspond to therapeutically acceptable temperatures for the bone tissue being treated, the extrudable fluid state in the third temperature range having a viscosity sufficiently low to permit injection into the bone tissue being treated; and (iv) the side chain crystallizable polymer comprises an amount of polar groups selected to increase the adhesion of the side chain crystallizable polymer to the bone tissue.