发明名称 |
Size-based analysis of fetal DNA fraction in maternal plasma |
摘要 |
A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA. |
申请公布号 |
AU2013229186(B2) |
申请公布日期 |
2016.11.24 |
申请号 |
AU20130229186 |
申请日期 |
2013.03.08 |
申请人 |
The Chinese University of Hong Kong |
发明人 |
Lo, Yuk Ming Dennis;Chan, Kwan Chee;Zheng, Wenli;Jiang, Peiyong;Liao, Jiawei;Chiu, Wai Kwun Rossa |
分类号 |
C12Q1/68;G06F19/18;G06F19/20 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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