| 发明名称 |
CHIMERIC ANTIGEN RECEPTOR FOR BISPECIFIC ACTIVATION AND TARGETING OF T LYMPHOCYTES |
| 摘要 |
Embodiments of the invention include methods and compositions related to improved cells encoding a chimeric antigen receptor that is specific for two or more antigens. In certain aspects the receptor encompasses two or more non-identical antigen recognition domains. The antigens are tumor antigens, in particular embodiments. |
| 申请公布号 |
US2016303230(A1) |
申请公布日期 |
2016.10.20 |
| 申请号 |
US201615077483 |
申请日期 |
2016.03.22 |
| 申请人 |
Baylor College of Medicine |
发明人 |
Ahmed Nabil M.;Grada Zakaria;Hegde Meenakshi;Baker Matthew;Shaffer Donald R. |
| 分类号 |
A61K39/395;C07K16/32;C07K14/725;C07K16/22;C07K14/705;A61K45/06;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cell comprising a chimeric antigen receptor (CAR) comprising two or more non-identical antigen recognition domains, wherein the CAR is further defined as comprising an exodomain comprising an antigen recognition domain specific for a first tumor antigen and an antigen recognition domain specific for a second tumor antigen, wherein the first or second tumor antigen is specific for an antigen selected from the group consisting of EphA2, IL13Rα2, and Tem8. |
| 地址 |
Houston TX US |
