发明名称 |
PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL) BENZOIC ACID AND ADMINISTRATION THEREOF. |
摘要 |
A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient. |
申请公布号 |
US2016303096(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
US201615001036 |
申请日期 |
2016.01.19 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
VERWIJS MARINUS JACOBUS;ALARGOVA ROSSITZA GUEORGUIEVA;KAUSHIK RITU ROHIT;KADIYALA IRINA NIKOLAEVNA;YOUNG CHRISTOPHER |
分类号 |
A61K31/443;A61K31/47;A61K9/16;A61K9/20;A61K9/00 |
主分类号 |
A61K31/443 |
代理机构 |
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代理人 |
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主权项 |
1. A tablet for oral administration comprising:
a. (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid) Form I in an amount ranging from about 25 mg to about 400 mg; b. a filler; c. a disintegrant; d. a surfactant; e. a lubricant; and f. at least one of a binder and a glidant. |
地址 |
BOSTON MA US |