发明名称 |
SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY |
摘要 |
Provided herein are substituted pyrimidine and triazine derivatives, including bicyclic pyrimidine derivatives, their pharmaceutical compositions, their preparation, and their use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs. In one embodiment, the pyrimidine and triazine derivatives are morpholino-pyrimidine, morpholino-triazine, pyridyl-pyrimidine, and pyridyl-triazine derivatives which are selective irreversible inhibitors of the p110a isoform of PI3K. |
申请公布号 |
WO2009120094(A3) |
申请公布日期 |
2010.01.28 |
申请号 |
WO2009NZ00038 |
申请日期 |
2009.03.26 |
申请人 |
AUCKLAND UNISERVICES LIMITED;REWCASTLE, GORDON WILLIAM;SHEPHERD, PETER ROBIN;CHAUSSADE, CLAIRE;DENNY, WILLIAM ALEXANDER;GAMAGE, SWARNALATHA AKURATIYA |
发明人 |
REWCASTLE, GORDON WILLIAM;SHEPHERD, PETER ROBIN;CHAUSSADE, CLAIRE;DENNY, WILLIAM ALEXANDER;GAMAGE, SWARNALATHA AKURATIYA |
分类号 |
C07D251/48;A61K31/53;A61P35/00;C07D251/18;C07D401/12;C07D403/12;C07D487/04 |
主分类号 |
C07D251/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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