摘要 |
<p>A process for the preparation of anastrozole which comprises: a) brominating 3,5-bis(2-cyanoprop-2-yl)toluene (II) in an organic solvent using a brominating agent to obtain 3,5- bis(2-cyanoprop-2-yl)benzylbromide (III); b) heating the reaction mass of step a) to the reflux temperature of the organic solvent for a period of time no longer than 3 hours; c) isolating and purifying the bromo intermediate (III) using an organic solvent; d) alkylating the bromo intermediate in the presence of a base, optionally a phase transfer catalyst, a 1,2,4-triazole and an organic solvent to obtain anastrozole; and e) isolating and purifying the anastrozole from an organic solvent.</p> |
申请人 |
CIPLA LIMITED;CURTIS, PHILIP, ANTHONY;SRINIVAS, PATHI, LAXMINARAYAN;KANKAN, RAJENDRA, NARAYANRAO;RAO, DHARMARAJ, RAMACHANDRA |
发明人 |
SRINIVAS, PATHI, LAXMINARAYAN;KANKAN, RAJENDRA, NARAYANRAO;RAO, DHARMARAJ, RAMACHANDRA |