OXAZOLIDIN-2-ONE-PYRIMIDINE DERIVATIVES AND THE USE THEREOF AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS

摘要

The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

主权项

1. A compound of the formula (I) and/or a pharmaceutically acceptable salt and/or solvate thereof, wherein, R1 is methyl, ethyl or hydroxymethyl; R2 is phenyl, which is unsubstituted or substituted in meta and/or para positions by 1 or 2 substituents independently selected from D, F or methoxy for the meta position and from D, F, methoxy, C1-C5-alkoxy, hydroxy-C2-C4-alkoxy or C1-C2-alkoxy-C2-C4-alkoxy for the para position, or pyridyl, which is unsubstituted or substituted in meta and/or para positions by 1 or 2 substituents independently selected from D, F or methoxy for the meta position and from D, F, methoxy, C1-C5-alkoxy, hydroxy-C2-C4-alkoxy or C1-C2-alkoxy-C2-C4-alkoxy for the para position, or a 5 membered monocyclic heteroaryl, containing 2 to 3 heteroatoms selected from N, O or S, which is unsubstituted or substituted by 1 to 2 substituents independently selected from D or F; and R3 is H or methyl.