| 摘要 |
Disclosed are compounds of Formula (I):;;and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein. |
| 主权项 |
1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
Ring B is a 6-membered aromatic ring, which ring is unsubstituted or substituted with 1 to 4 substituents independently selected from halo, —OH, —NH2, —CH3, —CH2F, —CHF2 and
—CF3; or is a 5- or 6-membered heteroaromatic ring having 1 to 3 ring heteroatoms independently selected from O, N and S, which ring is unsubstituted or substituted with 1 to 3 substituents independently selected from halo, —OH, —NH2, —CH3, —CH2F, —CHF2 and —CF3; A1 is —H or C1-3 alkyl; and A2 is —C(R7)(R8)—(CH2)p—N(R9)R10; or A1 and A2, together with the carbon atom to which they are attached, form m is 0, 1 or 2; n1 is 1 or 2; n2 is 0 or 1; n3 is 0 or 1; p is 0 or 1; R is —H or C1-C3 alkyl; or R is —CH2—(X), —CH2CH2—(X), —CH2—(Z) or —CH2CH2—(Z); each instance of R5 independently is halo, —CH3 or ethyl; each instance of R6 independently is halo or —CH3; R7 is —H or C1-C3 alkyl; R8 is —H or C1-C3 alkyl which is unsubstituted or substituted with C3-C6 cycloalkyl; R9 is —H, C1-C4 alkyl or C3-C6 cycloalkyl; and R10 is —H or C1-C3 alkyl; or R9 and R8, together with the atoms to which they are attached, form or R9 and R10, together with the nitrogen atom to which they are attached, form w is 0, 1 or 2; X is CH or CH2; and Z is CH, CH2 or O. |
