ELECTROSTATIC CHARGE-INDUCED COATING OF MEDICAL DEVICES WITH BIOMOLECULES

摘要

Methods, systems, and kits provide robust and biologically active coatings for implanted medical devices. The methods are based on electrostatic attraction between a non-conductive material surface on the medical device and a coating material including a charged biopolymer or pharmaceutical agent. Surface charge is induced or enhanced in the non-conductive material using a physical method. The methods are applicable to a wide variety of non-conductive substrate materials and coatings containing any of a wide variety of biological molecules and pharmaceutical agents.