METHOD FOR SIMULATING THE INTERACTION OF CHEMICAL SUBSTANCES AND LIVING ORGANISMS

摘要

A method for determining the interaction of one or more chemical active compounds with organisms. The method comprises selecting at least one compound and analyzing its physiko-chemical and/or biochemical characteristics including its pharmacokinetic properties in various anatomical and physiological compartments of the organism in question. The relevant physiological compartments are characterized with respect to the compound's various pharmacokinetic properties that may vary with the mode of administering the compound. A combined system of coupled differential equations is then used to simulate a concentration-time curve of the active compound in selected compartments.