| 摘要 |
Devices for optical monitoring and rapid analysis of a drying droplet are presented and include a droplet deposition means (10), an optical recording means (60), and a computer control and image analysis means. In several preferred embodiments, a pipette (30) is used to deposit one or more droplets in parallel onto a slide, a plate or a film, and a digital microscope is positioned either above or below the droplet to record a timed sequence of images of the process of drying thereof. Various chemical compounds coating the deposition slide can be used to enhance the test further. Image analysis includes data filtering, dividing the image into a plurality of overlapping windows, and analysis of formation and change in patterns over time. If used with biological fluids, the devices and methods of the invention can be used for rapid diagnosis of a variety of conditions and diseases. |
