TRANSGENIC SILKWORM CAPABLE OF PRODUCING FUNCTIONAL ANTIBODY MOLECULE
摘要
<p>Disclosed is a novel means for producing a recombinant antibody at low cost and in a large quantity. Specifically disclosed is a transgenic silkworm in which a structural gene for each of an H-chain and an L-chain of an antibody is integrated in the chromosome. In the transgenic silkworm, two H-chain molecules and two L-chain molecules are linked via a disulfide bond. The transgenic silkworm can secrete a functional antibody molecule having an activity of binding to an antigen into a cocoon. Also disclosed is a method for producing an antibody, which comprises collecting the functional antibody molecule from a cocoon of the silkworm.</p>
