DIVALENT VACCINE COMPOSITIONS AND THE USE THEREOF FOR TREATING TUMORS

摘要

The invention describes vaccine compositions combined in the same proportion with the extracellular domains of growth factor receptors Her1 and Her2 or fragments thereof and furthermore very small size proteoliposomes derived from proteins of the outer membrane of Neisseria meningitidis and GM3 ganglioside (VSSP-GM3), administered subcutaneously. The disclosed compositions, which induce the production of antibodies are used for the treatment of malignancies and offer advantages because they completely remove the tumor mass thus preventing tumor regression due to the emergence of resistant variants.

主权项

1- A vaccine composition comprising the ECDs of Her1 and Her2 receptors or fragments thereof in the same proportion and very small size proteoliposomes derived from proteins of the outer membrane of Neisseria meningitidis and GM3 (VSSP-GM3) to induce an immune response against malignant tumors that express Her1 and Her2 receptors.