| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a Th2-mediated immunopotentiator causing strong Th2-mediated immune activation in vivo, and to provide a method for producing the immunopotentiator. <P>SOLUTION: A treated material obtained by subjecting Nippostrongylus brasiliensis as a kind of digestive tract helminth parasite to ultrasonic crushing treatment and a TritonX-114-containing water solution as one of surfactant are mixed, and thereafter, the water layer and surfactant layer are subjected to layer separation treatment. A surfactant-removed extracted fraction obtained by removing the TritonX-114, from a surfactant fraction obtained by extracting the surfactant layer as the surfactant fraction, by an ethanol precipitation method has an action of increasing an IgE amount as the index of Th2-mediated immunopotentiation, increasing the number of eosinophils or increasing IL-4 expression level by oral administration for a single time. <P>COPYRIGHT: (C)2012,JPO&INPIT |
