KERATIN-BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION

摘要

The present invention pertains to keratin-binding polypeptides derived from the keratin-binding domain B (KBD-B) of desmoplakin, which have improved structural or functional properties in comparison to the native KBD-B. It furthermore pertains to the preparation of said polypeptides, to compositions comprising said polypeptides, and to their use in cosmetic and therapeutic applications. A method for identification of such improved keratin-binding proteins is also presented. Said method is based on a novel three dimensional model of keratin which is also part of present invention.