METHODS AND COMPOSITIONS RELATING TO HIGH RESOLUTION STRUCTURE OF NON-SEGMENTED NEGATIVE STRAND VIRUS L PROTEINS

摘要

Described herein are methods and compositions relating to the high resolution 3D structure determination for non-segmented negative strand (NNS) virus multifunction L proteins. High resolution 3D structure as described permits the application of a range of rational drug design and screening approaches to the identification of inhibitors of any of the varying functions of the NNS virus L proteins and thereby facilitates the identification of antiviral agents.