DAPAGLIFLOZIN CRYSTALLINE FORM AND PREPARATION METHOD THEREOF

摘要

A crystalline form of dapagliflozin represented by formula (I) is provided. The crystalline form has a characteristic absorption peak in an X-ray powder diffraction pattern at a diffraction angle 2θ and interplanar spacing (value d) at about 4.318 (20.45) in an X-ray powder diffraction pattern. The crystalline form can be prepared by dissolving dapagliflozin in good organic solvents, adding poor solvents, stirring to crystallization, filtering and drying. The provided crystalline form of dapagliflozin has the following features: good solubility, low hygroscopicity, high stability and good preparation reproducibility.;

主权项

1. A crystalline form of dapagliflozin represented by formula (I):the crystalline form having a characteristic X-ray powder diffraction (XRPD) peak at:
Angle (2θ) d-Value (Angstrom) about 4.318 about 20.45.