THERAPEUTIC POLYMERIC NANOPARTICLE COMPOSITIONS WITH HIGH GLASS TRANSITION TEMPERATURE OR HIGH MOLECULAR WEIGHT COPOLYMERS

摘要

The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.

主权项

1. A method for identifying therapeutic polymeric nanoparticle compositions with a desired therapeutic agent release rate profile, comprising:
a) providing a first aqueous suspension of at least one first plurality of polymeric nanoparticles each comprising a therapeutic agent, a block copolymer having at least one hydrophobic portion and at least one hydrophilic portion; b) determining the nanoparticle glass transition temperature for the first aqueous suspension; c) varying the amount or molecular weight of the hydrophobic portion of the block copolymer to provide a second aqueous suspension comprising a plurality of polymeric nanoparticles each comprising the therapeutic agent, if the glass transition temperature of step b) is below 37° C.; d) repeating steps b) and c) until an aqueous suspension with a glass transition temperature of about 37° C. and about 50° C. and the desired therapeutic agent release rate profile is obtained.