发明名称 |
NOVEL GENE PARTICIPATING IN EPIDERMAL DIFFERENTIATION AND USE THEREOF |
摘要 |
<p>A high-throughput in situ hybridization system was applied to the mouse foot pad epidermis to identify novel genes involved in epidermal differentiation. As a result, epidermal expression patterns were detected for about 100 unique mRNAs. Of these, two novel secreted proteins, dermokine-± and -², which are expressed in the suprabasal layer of the differentiated epithelia, were successfully identified. Further, the gene encoding the above proteins was found to constitute a novel gene complex (SSC).</p> |
申请公布号 |
EP1739171(A1) |
申请公布日期 |
2007.01.03 |
申请号 |
EP20050719773 |
申请日期 |
2005.03.02 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
MATSUI, TAKESHI;KISUMI, FUMIE;KINOSHITA, YOKO |
分类号 |
A61K9/00;C12N15/09;A61K31/7088;A61K31/7105;A61K38/00;A61K39/395;A61K48/00;A61P17/00;A61P17/06;A61P17/16;A61P35/00;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/68;G01N33/50 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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