发明名称 |
COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING HOST CELL PROTEIN IN CELL LINES AND RECOMBINANT POLYPEPTIDE PRODUCTS |
摘要 |
Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided. |
申请公布号 |
EP3044323(A2) |
申请公布日期 |
2016.07.20 |
申请号 |
EP20140844121 |
申请日期 |
2014.09.12 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
GUNAWAN, FENY;HSIAO, YI-CHUN;KRAWITZ, DENISE C.;LIN, MARGARET S.;VANDERLAAN, MARTIN;VIJ, RAJESH;YUK, INN H.;ZHU-SHIMONI, JUDITH |
分类号 |
G01N33/573;C07K16/40;C12N5/07;C12P21/08 |
主分类号 |
G01N33/573 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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