发明名称 |
4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS |
摘要 |
The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the 4-carboxybenzylamino derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the 4-carboxybenzylamino derivatives in vivo. |
申请公布号 |
EP3103791(A1) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20160169994 |
申请日期 |
2008.06.24 |
申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
Harrington, Paul;Heidebrecht, Richard W. Jr.;Kattar, Solomon;Miller, Thomas A.;Otte, Karin M.;Siliphaivanh, Phieng;Tempest, Paul;Wilson, Kevin J.;Witter, David |
分类号 |
C07C237/40;A61K31/17;A61P35/00;C07D207/08 |
主分类号 |
C07C237/40 |
代理机构 |
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代理人 |
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