| 摘要 |
FIELD: biochemistry.SUBSTANCE: present invention relates to biochemistry, particularly to a cyclic peptide possessing antineoplastic and antiangiogenic activity, having one of SEQ ID NO: 1-76. Present invention discloses a pharmaceutical composition, a pharmaceutical combination and use of said cyclic peptide for treating malignant growths or disorders associated with undesirable cell proliferation or undesirable angiogenesis. Pharmaceutical combination of said cyclic peptide in concentration of 12.5-200 mcM with anticancer drug in concentration of 1-2,000 nM has high antineoplastic activity. Present invention discloses means for diagnosis of malignant new growths, comprising a cyclic peptide and radiopharmaceutical agent, for example fluorescent particle.EFFECT: present invention widens range of means of controlling malignant new growths.14 cl, 21 dwg, 8 tbl, 21 ex |
