发明名称 Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain
摘要 The use of 1-phenyl-3-dimethylaminopropane compounds for the treatment of rheumatoid pain, especially rheumatoid arthritic pain, very especially preferably chronic rheumatoid arthritic pain.
申请公布号 US2016346228(A1) 申请公布日期 2016.12.01
申请号 US201615232419 申请日期 2016.08.09
申请人 Gruenenthal GmbH 发明人 JAHNEL Ulrich;SCHIENE Klaus
分类号 A61K31/137 主分类号 A61K31/137
代理机构 代理人
主权项 1. A method of treating rheumatoid pain in a subject in need thereof, said method comprising administering to said subject an effective rheumatoid pain relieving amount of a 1 -phenyl-3-dimethylamino-propane compound corresponding to formula I: wherein X is OH, F, Cl, OC(O)CH3 or H; R1 is a saturated and unsubstituted, branched or unbranched C1-4-alkyl group; R2 and R3 are each independently selected from the group consisting of H and saturated and unsubstituted, branched or unbranched C1-4-alkyl; or R2 and R3 together form a saturated or unsaturated, unsubstituted or mono- or polysubstituted C5-6-cycloalkyl group; at least three of R9 to R13 denote H, and the remainder of R9 to R13 are each independently selected from the group consisting of H, Cl, F, OH, CF2H, CF3, saturated and unsubstituted, branched or unbranched C1-4 alkyl, OR14 and SR14, wherein R14 denotes a saturated and unsubstituted, branched or unbranched C1-3-alkyl group; or R11 and R12 together form a 3,4-OCH=CH ring; or a physiologically compatible salt thereof.
地址 Aachen DE