| 发明名称 |
METHOD OF DRUG FORMULATION BASED ON INCREASING THE AFFINITY OF ACTIVE AGENTS FOR CRYSTALLINE MICROPARTICLE SURFACES |
| 摘要 |
Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle. |
| 申请公布号 |
US2016346212(A1) |
申请公布日期 |
2016.12.01 |
| 申请号 |
US201615233794 |
申请日期 |
2016.08.10 |
| 申请人 |
MannKind Corporation |
发明人 |
Hokenson Mark;Oberg Keith A. |
| 分类号 |
A61K9/16;A61K9/50;A61K9/00;A61K38/29;A61K38/26;A61K38/13;A61K38/28;A61K38/22 |
主分类号 |
A61K9/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for making a microparticle coated with an active agent, the method comprising:
i. combining (a) a microparticle comprising crystalline fumaryl diketopiperazine, (b) an active agent, and (c) a solvent for said active agent thereby forming a suspension of said microparticles in a solution of said active agent; ii. adding an active agent modifier to said solution wherein adding said active agent modifier causes adsorption of said active agent onto said microparticle. |
| 地址 |
Valencia CA US |
