DOSAGE UNIT FOR SUBLINGUAL, BUCCAL OR ORAL ADMINISTRATION OFWATER-INSOLUBLE PHARMACEUTICALLY ACTIVE SUBSTANCES

摘要

One aspect of the invention relates to a pharmaceutical dosage unit for s ublingual, buccal, pulmonary or oral administration, said dosage unit having a weight of 20-500 mg and comprising 1-80 wt.% of a microgranulate that is distributed throughout a solid hydrophilic matrix; said microgranulate being characterised in that it: has a volume weighted average diameter of 5-100 m ; contains at least 0.01 wt.%, preferably at least 0.1 wt.% of one or more w ater-insoluble pharmaceutically active substances; contains at least 10 wt.% , preferably at least 20 wt.% of an emulsifier component; and is capable of forming a micro-emulsion upon contact with saliva or water. The dosage units of the present invention achieve the inherent benefits of oral delivery whi lst at the same time realising a high transmucosal absorption rate of the ca nnabinoids contained therein. Other aspects of the present invention relate to the use of the aforementioned dosage units in the therapeutic or prophyla ctic treatment and to a process for the manufacture of said dosage units.