TREATMENT AND PREVENTION OF STROKE AND OTHER NEUROLOGICAL DISORDERS

摘要

Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.

主权项

1. A method of treating or preventing an ischemic or hemorrhagic stoke or transient ischemic attack (TIA) comprising administering to a subject in need thereof from about 0.001 to about 1.0 mg/kg of isoxsuprine or a pharmaceutically acceptable salt, analog or derivative thereof.