发明名称 改良されたオリゴヌクレオチドおよびそのオリゴヌクレオチドを含む医薬組成物
摘要 The purpose of the present invention is to provide a native linear RNA molecule which can be produced in a simple manner and has nuclease resistance. The present invention provides an RNA molecule which is characterized by comprising a nucleotide sequence represented by general formula (1) or a nucleotide sequence substantially comprising the above-mentioned nucleotide sequence but having the mutation in one to several nucleotides therein, and is also characterized by having nuclease resistance capability. 5'-GGUUAGGGUUACX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16ACGAAACAAAAAAUGG-3' (1) [In formula (1), X1 to X16 independently represent any nucleotide selected from adenine, cytosine, guanine and uracil.]
申请公布号 JP6021018(B2) 申请公布日期 2016.11.02
申请号 JP20130518196 申请日期 2012.05.30
申请人 国立大学法人豊橋技術科学大学 发明人 梅影 創;越智 明徳;菊池 洋
分类号 C12N15/113;A61K31/7105;A61K31/712;A61K31/7125;A61K49/00;A61P35/00 主分类号 C12N15/113
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