SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

摘要

Provided herein are diaminopyrimidyl Compounds having the following structures:;wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

主权项

1. A method for the treatment or prevention of PKC-theta mediated disorder comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein: X is CN or CF3; L is (C1-4 alkyl); R1 is substituted or unsubstituted heteroaryl; and R2 is substituted or unsubstituted cycloalkyl, wherein the PKC-theta mediated disorder is graft-versus-host disease, organ transplant rejection, psoriasis, Duchenne muscular dystrophy, rheumatoid arthritis, insulin resistance, myasthenia gravis, multiple sclerosis, colitis, psoriatic arthritis, ankylosing spondylitis, atopic dermatitis, Sjogren syndrome, asthma, or lupus.