MODIFIED 5'- PHOSPHONATE AZIDOTHYMIDINE-POTENTIAL ANTI-VIRAL PREPARATIONS

摘要

The invention relates to molecular biology, virology and medicine, in particular to novel 3'azido-3'-dezoxythymidine-phosphonates of general formula (I), wherein R is alkyl groups including groups containing halogen atoms, carboxy, hydroxy, alkoxy and acyloxy- groups and substituted aminocarbonyl groups. The inventive compounds can be used in the form of anti-viral agents since they are low-toxic, efficiently inhibit the reproduction of a type 1 immunodeficiency virus in the culture of MT-4 cells and generate azidothymidine in mammal organisms, thereby ensuring the gradual increase thereof in blood.