VOXEL-BASED METHODS FOR ASSESSING SUBJECTS USING MOLECULAR MAGNETIC RESONANCE IMAGING

摘要

The subject matter disclosed herein relates to methods for diagnosing a neurological disorder in a subject. In certain aspects, the methods described herein involve determining one or more critical areas in the brain from molecular Magnetic Resonance Imaging (MRI) data where two groups differ and measuring MRI signal within determined critical areas in a new subject in order to assign risk or diagnosis.

主权项

1. A computer-implemented method for diagnosing or determining risk of a neurological disorder in a subject, the method comprising:
(a) determining the presence of a magnetic resonance signal from an administered ligand in at least one individual in a control group and at least one individual in a reference group to generate primary brain scan image voxel data of ligand distribution in a brain of at least one individual in a control group and at least one individual in a reference group, (b) generating secondary brain scan image data for the individuals in the control and reference groups, wherein the secondary scan brain image data is generated using a different type of brain scan than the primary brain scan image data, (c) generating a probability-corrected time-intensity curve data for each voxel in the primary brain scan image of the at least one individual in the control and reference group, (d) processing the probability-corrected time-intensity curve data of the at least one individual in the control and reference group to generate a voxel binding outcome map data of the at least one individual in the control and reference group, (e) transforming the voxel binding outcome map data of the at least one individual in the control and reference group into a normalized space to generate a normalized voxel binding outcome map data of the at least one individual in the control and reference group (f) processing the normalized voxel binding outcome map data of the at least one individual in the control and reference group using statistical analysis to identify one or more voxels of interest (VOI) in the normalized voxel binding outcome map data to generate a VOI map data for differentiating of the at least one individual in the control and reference group, and (g) applying the VOI map data to a voxel binding outcome map data of a test subject to generate a mean masked binding value to diagnose or determine risk of a neurological disorder in the subject wherein the voxel binding outcome map data of said test subject is generated from Magnetic Resonance Imaging (MRI) using a MRI scanner.