MODIFIED DNA QUADRUPLEX-FORMING OLIGONUCLEOTIDES AND METHODS OF USE

摘要

Oligonucleotides according to the following Formula I are provided herein: 5′-Xa-Q-Yb-3′ wherein X and Y are each independently selected from the group consisting of a lipid and a polyethylene glycol; Q is a quadruplex-forming guanine-rich promoter gene oligonucleotide (GPGO); a is 0 or 1; and b is 0 or 1, wherein the sum of a+b=1 or 2. Also provided are compositions including Formula I oligonucleotides and methods of their use in inhibiting cell growth, treating cancer, and treating tumors.

主权项

1. An oligonucleotide according to the following Formula I:
5′-Xa-Q-Yb-3′   Formula I wherein: X and Y are each independently selected from the group consisting of a lipid and a polyethylene glycol; Q is a quadruplex-forming guanine-rich promoter gene oligonucleotide (GPGO); a is 0 or 1; and b is 0 or 1, wherein the sum of a+b=1 or 2.