| 发明名称 |
METHOD OF QUALIFYING CELLS |
| 摘要 |
A method of qualifying whether a cell population is a suitable therapeutic is disclosed. The method comprises:
(a) incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP for at least two days to obtain a population of differentiated MSCs; and(b) analyzing the expression of CD49a in the differentiated MSC population, wherein an amount of CD49a above a predetermined level indicative of the cell population being suitable as a therapeutic. |
| 申请公布号 |
US2016334392(A1) |
申请公布日期 |
2016.11.17 |
| 申请号 |
US201515113105 |
申请日期 |
2015.02.11 |
| 申请人 |
BRAINSTORM CELL THERAPEUTICS LTD. |
发明人 |
GOTHELF Yael;LEVY Yosef |
| 分类号 |
G01N33/50;C12N5/0775;A61K35/28 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of qualifying whether a cell population is a suitable therapeutic comprising:
(a) incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP for at least two days to obtain a population of differentiated MSCs; and (b) analyzing the expression of CD49a in the differentiated MSC population, wherein an amount of CD49a above a predetermined level indicative of the cell population being suitable as a therapeutic. |
| 地址 |
Patach-Tikva IL |
