| 摘要 |
A method for detecting, in a biological sample, at least two microorganisms belonging to two different taxa, represented by intensity vectors Pj obtained by a multidimensional measuring technique, comprises: ■ acquiring a digital signal from the biological sample by means of measurement technology; ■ determining an intensity vector x on the basis of the acquired digital signal; ■ constructing a set {Ŷl} of candidate models Ŷl =(Ŷj, Ŷo)l modelling intensity vector x according to the equation: expression in which: expression in which: o ∀j ∈ [[1, K]], Pj (a)=:&Sgr;i K=1aijPi; and o ∀(i,j) ∈ [[1, K]]2, aij is a predefined coefficient; selecting a candidate model Ŷsel from set {Ŷl} according to the equation: Ŷsel= argmin(Cv (Ŷl) + Cc(Ŷl) expression in which: o Cv(Ŷl) is a criterion quantifying a reconstruction error between the intensity vector of biological sample x and the reconstruction of intensity vector xl by a candidate model (Ŷl); and o Cv(Ŷl) is a criterion quantifying the complexity of a candidate model Ŷl; and determining the presence in the biological sample of at least two taxa from when at least two components of vector Ŷj; of Ŷsel are greater than a positive threshold. |
