The present invention relates to enhancing RNA expression in a cell such as a cell transfected with RNA by reducing the activity of RNA-dependent protein kinase (PKR). Thus, the present invention provides methods for expressing RNA in a cell comprising the step of reducing the activity of RNA-dependent protein kinase (PKR) in the cell. Reducing the activity of RNA-dependent protein kinase (PKR) in the cell increases the stability of RNA and/or increases the expression of RNA in the cell.
申请公布号
AU2011335428(B2)
申请公布日期
2016.12.22
申请号
AU20110335428
申请日期
2011.12.02
申请人
Universitatsmedizin der Johannes Gutenberg-Universitat Mainz;Translationale Onkologie an der Universitatsmedizin der JGU Mainz GGMBH (TRON);BioNTech AG