摘要 |
Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C-, whereby at least two of the groups Y1 to Y4 denot e a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydr ogen, methyl or ethyl; and R10 and R11 independent ly represent e.g. hydroge n or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevent ion of acute and chronic neurological disorders.
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申请人 |
MERZ PHARMA GMBH & CO. KGAA |
发明人 |
GUTCAITS, ALEKSANDRA;DEKUNDY, ANDRZEJ;FOTINS, JURIS;HECHENBERGER, MIRKO;JATZKE, CLAUDIA;HENRICH, MARKUS;KAUSS, VALERJANS;ZEMRIBO, RONALDS;WEIL, TANJA;PARSONS, CHRISTOPHER GRAHAM RAPHAEL;DANYSZ, WOJCIECH;NAGEL, JENS;MUELLER, SIBYLLE;ERDMANE, ELINA;KAULINA, LARISA |