Compositions of fine solid particles of selective PDE4 inhibitors for delivery to the lungs by inhalation

摘要

Described is an inhaled formulation comprising 9-cyclopentyl-5,6-dihydro-7-ethyl-3-(thien-2-yl)-9H-pyrazolo[3,4-c]1,2,4-triazolo[4,3-alpha]pyridine or a pharmaceutically acceptable salt thereof, wherein the formulation is capable of delivering the compound as solid particles to the lung. The particles are less than 20 micrometers in diameter and the formulation is capable of being delivered to the lung by a dry powder inhaler. This inhaled formulation can be used in the manufacture of a medicament for the treatment of a disease treatable by the inhibition of PDE4 such as a respiratory disease, for example asthma or chronic obstructive pulmonary disease.