Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
申请公布号
WO2008115732(A2)
申请公布日期
2008.09.25
申请号
WO2008US56527
申请日期
2008.03.11
申请人
ELI LILLY AND COMPANY;KORYTKO, ANDREW, IHOR;MARQUIS, DAVID, MATTHEW;SMITH, ERIC, MICHAEL;SWANSON, BARBARA, ANNE
发明人
KORYTKO, ANDREW, IHOR;MARQUIS, DAVID, MATTHEW;SMITH, ERIC, MICHAEL;SWANSON, BARBARA, ANNE